The benefits of Pulse-driven ICSIknchua
What is Infertility?
Infertility is defined as not being able to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse between a man and a woman. Around 15% of couples in Singapore faced infertility . Fortunately, there are various ways to treat infertility. ICSI (intracytoplasmic sperm injection) is one of the treatment methods to overcome infertility.
What Is ICSI Treatment?
Intracytoplasmic Sperm Injection (ICSI) is a specialised form of In Vitro Fertilisation (IVF) that is often used including for the treatment of severe cases of male-factor infertility. In the ICSI process, a tiny needle called a micropipette is used to inject a single sperm into the center of the egg. Once fertilisation occurs, the fertilised egg (now called an embryo) grows in a laboratory for 1 to 5 days before it is transferred to the woman’s uterus.
What Is Pulse-driven ICSI Treatment?
Pulse-driven ICSI is a technique that minimises damage to the egg and increases egg fertilisation rate as compared to conventional ICSI. Some studies have demonstrated high fertilisation rate (90%) and low egg degeneration rate (1%) in Pulse-driven ICSI and is shown to be efficient and safe .
Pulse-driven ICSI uses piezoelectric pulses to aid in the injection of a sperm into the egg. This technique uses a blunt pipette tip instead of a sharp tip which is typically used in conventional ICSI. In this way, it makes Pulse-driven ICSI less invasive.
In summary, Pulse-driven ICSI causes less deformation of the zona pellucida membrane compared to conventional ICSI. It thus reduces the risk of injury to the egg, and increases fertilisation rate.
 Chandra, A. M. (n.d.). Infertility in Women: Causes and Treatment Options. HealthXchange. Retrieved January 20, 2023, from https://www.healthxchange.sg/women/pre-pregnancy/infertility-women-causes-treatment#:~:text=About%2015%20per%20cent%20of,problem%20lies%20with%20both%20partners.
 Hiraoka, K., Kitamura, S., Kuwayama, M., Kim, J., Turan, V., & Oktay, K. (2014). PiezoICSI using ultra-thin needle dramatically improves oocyte survival and fertilization without detrimental effect on embryo development and implantation ability as compared with conventional-ICSI. Fertility and Sterility, 102(3), e32