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IVF Case Study #1 – PCOS with low sperm count

Mrs Allie (not actual name) is a 34-year-old female.

Mr. Allie is a 43-year-old male, a social smoker and drinker.

Mr. and Mrs. Allie were married for 2 years and have been trying to conceive a baby naturally. However, they had no success in conceiving. They were unsure of the reason behind their infertility and decided to seek medical advice from professionals. The couple came to Alpha IVF Centre for a fertility check and were keen for fertility treatment.

It was discovered that Mrs. A had polycystic ovary syndrome (PCOS). On the other hand, Mr. Allie had his semen analysed and  he was found to have a very low sperm count and is at risk of having azoospermia (no sperm count in semen). Dr Tan advised the couple to try out IVF treatment to increase the chances of successful pregnancy. Dr Tan explains that the fertilization is assisted via intracytoplasmic sperm injection (ICSI) which is beneficial for poor sperm quality or severe male factor infertility. Dr Tan also advised the husband to have his sperm cryopreserved for future treatments. The couple decided to follow Dr Tan’s advice and attended IVF and financial counselling on the same day of visit. The IVF counselling included the explanation of  possible complications, like the possibility of multiple pregnancies and/or ovarian hyperstimulation syndrome (OHSS) when receiving fertility treatments, while financial counselling explains the details of the cost and schedule of the entire IVF journey. Mrs Allie was told to start her ovulation stimulation with medication and injections on  Day 2 of her menstruation.

After 2 weeks of stimulation done at home, Mrs Allie came to Alpha IVF Centre to do an oocyte pick-up (OPU) under sedation in the care of an anaesthetist. Dr. Tan retrieved 20 eggs on that day.

19 eggs were (transferred (injected into her womb) 15 eggs were fertilised, and 5 usable blastocysts were formed. Out of the 5 usable blastocysts, 2 of them were of good grade, 2 were fair/good grade, 1 was fair grade. All of them were frozen and stored until the couple is ready to transfer the embryos. When the couple has decided to go for the frozen embryo transfer (FET), Mrs Allie booked an appointment with Dr Tan on her first day of menses. After much discussion, the couple and Dr Tan finalized the decision to transfer 1 of her best grade embryos on the scheduled FET date. On the 10th day post FET, Mrs A were tested beta positive, indicating a successful pregnancy.

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